Cytochrome P-450 is sometimes called the microsomal carbon monoxide-binding pigment. It is present in the microsomal fraction of several animal tissues, and also in the mitochondrial fraction of adrenal cortex, but not in the; mitochonria of other tissues. Cytochrome P-450, the liver microsomal drugmetabolizin?; enzyme is membrane-bound and fraction as multicomponent electron- transport system for the metabolism of a variety of endogenous substrates (such as steroids; fatty acids, and bile acids) and exogenous substances (such as drugs, carcinogens, insecticides, and many other foreign compounds).
The effect . of estrous cycle and preimplantation on the levels of hepatic microsomal _Cytochrome P-450 in mice were determined.._
In effect of estrous cycle on microsomal Cytochrome P-450 level, the most increment was at estrus. The content of Cytochrome P-450 was increased significantly at pregnant Day 3 of preimplantation.
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